A Recombinant Human Hemoglobin with Anti-sickling Properties Greater than Fetal Hemoglobin

doi:10.1074/jbc.m402578200

Article

A Recombinant Human Hemoglobin with Anti-sickling Properties Greater than Fetal Hemoglobin

1 Jun 2004

Abstract excerpt

A new recombinant, human anti-sickling beta-globin polypeptide designated beta(AS3) (betaGly(16) --> Asp/betaGlu(22) --> Ala/betaThr(87) --> Gln) was designed to increase affinity for alpha-globin. The amino acid substitutions at beta22 and beta87 are located at axial and lateral contacts of the sickle hemoglobin (HbS) polymers and strongly inhibit deoxy-HbS polymerization. The beta16 substitution confers the...

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