Article
Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.
Genetics - 1 Apr 2006
Mahoney Matt B, Parks Annette L, Ruddy David A, Tiong Stanley Y K, Esengil Hanife, Phan Alexander C, Philandrinos Panos, Winter Christopher G, Chatterjee Runa, Huppert Kari, Fisher William W, L'Archeveque Lynn, Mapa Felipa A, Woo Wendy, Ellis Michael C, Curtis Daniel
Abstract excerpt
Presenilin is the enzymatic component of gamma-secretase, a multisubunit intramembrane protease that processes several transmembrane receptors, such as the amyloid precursor protein (APP). Mutations in human Presenilins lead to altered APP cleavage and early-onset Alzheimer's disease. Presenilins also play an essential role in Notch receptor cleavage and signaling. The Notch pathway is a highly conserved...
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