Article
Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation.
BMC biotechnology - 1 Jan 2001
Misra R P, Bronson S K, Xiao Q, Garrison W, Li J, Zhao R, Duncan S A
Abstract excerpt
BACKGROUND: Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing alleles that cause lethality because lines of founder mice cannot be established. This is frustrating given that such alleles often reveal crucial aspects of gene function. For this reason techniques that facilitate the generation of embryos...
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