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Article

Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening.

Circulation research - 15 Feb 2013

Ding Yonghe, Liu Weibin, Deng Yun, Jomok Beninio, Yang Jingchun, Huang Wei, Clark Karl J, Zhong Tao P, Lin Xueying, Ekker Stephen C, Xu Xiaolei

Abstract excerpt

RATIONALE: Mutagenesis screening is a powerful genetic tool for probing biological mechanisms underlying vertebrate development and human diseases. However, the increased colony management efforts in vertebrates impose a significant challenge for identifying genes affecting a particular organ, such as the heart, especially those exhibiting adult phenotypes on depletion. OBJECTIVE: We aim to develop a facile...

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Identifiers

PMID: 23283723
DOI: 10.1161/CIRCRESAHA.112.300603
PMCID: PMC3603352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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