Article
Clinical significance of a NAD(P)H: quinone oxidoreductase 1 polymorphism in patients with disseminated peritoneal cancer receiving intraperitoneal hyperthermic chemotherapy with mitomycin C.
Pharmacogenetics - 1 Jan 2002
Fleming Ronald A, Drees Jeffrey, Loggie Brian W, Russell Gregory B, Geisinger Kim R, Morris Reba T, Sachs Debbie, McQuellon Richard P
Abstract excerpt
Recent data indicate that NAD(P)H: quinone oxidoreductase 1 (NQO1) is important in the activation of mitomycin C. A polymorphism in human NQO1 (609C>T) is associated with diminished NQO1 activity. The purpose of our study was to determine the effect of the 609C>T polymorphism on tumor NQO1 activity and overall survival in patients with disseminated peritoneal cancer receiving intraperitoneal mitomycin C therapy....
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