Article
Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk.
Cancer research - 1 Jul 1999
Chen H, Lum A, Seifried A, Wilkens L R, Le Marchand L
Abstract excerpt
The NAD(P)H:quinone oxidoreductase gene, NQO1, often carries a C-->T transition at bp 609, which has been associated with a reduced enzymatic activity and which may result in altered metabolic activation of tobacco smoke procarcinogens. We tested the association of this polymorphism with lung cancer risk in a population-based case-control study of 327 cases and 440 controls of Caucasian, Japanese, or Native...
Topics
- Alleles
- Asian People
- Case-Control Studies
- Cytosine
- Female
- Genetic Variation
- Genotype
- Hawaii
- Humans
- Japan
- Lung Neoplasms
- Male