Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1).

doi:10.1016/s0006-2952(01)00769-9

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Article

Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1).

Biochemical pharmacology - 15 Nov 2001

Phillips R M, Burger A M, Fiebig H H, Double J A

Abstract excerpt

Pharmacogenetic analysis of polymorphisms in drug metabolizing enzymes is currently generating considerable interest as a means of individualizing patient therapy. Recent studies have suggested that patients that are homozygous for a polymorphic variant (a C to T transition at position 609 of the...

Topics

Animals
Antibiotics, Antineoplastic
Disease Models, Animal
FMN Reductase
Genotype
Humans
Mice
Mice, Nude
Mitomycin
NADH, NADPH Oxidoreductases
Neoplasm Transplantation
Neoplasms, Experimental
Polymorphism, Genetic
Transplantation, Heterologous

Source

Open in PubMed

Identifiers

PMID: 11709197
DOI: 10.1016/s0006-2952(01)00769-9

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-11709197-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Tumor Cells, Cultured

Xenograft Model Antitumor Assays