Article
Association between NAD(P)H: quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract.
International journal of cancer - 10 Nov 2003
Sarbia Mario, Bitzer Monika, Siegel David, Ross David, Schulz Wolfgang A, Zotz Rainer B, Kiel Sybille, Geddert Helene, Kandemir Yasemin, Walter Alexandra, Willers Reinhart, Gabbert Helmut E
Abstract excerpt
NQO1 is an antioxidant enzyme, important in the detoxification of environmental carcinogens. A single nucleotide polymorphism (C-->T) at position 609 of the NQO1 cDNA has been associated with susceptibility to tumours induced by chemical carcinogens. In our case-control study, we determined the p...
Topics
- Adenocarcinoma
- Adult
- Aged
- Case-Control Studies
- Esophageal Neoplasms
- Female
- Gastroesophageal Reflux
- Genotype
- Humans
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Odds Ratio
- Point Mutation