Article
A model for the phenotypic presentation of Werner's syndrome.
Experimental gerontology - 1 Jan 2000
Ostler E L, Wallis C V, Sheerin A N, Faragher R G A
Abstract excerpt
Werner's syndrome (WS) is a valuable model of accelerated ageing and results from mutations in a recQ helicase (wrn). WS fibroblasts show a mutator phenotype, replication fork stalling, increased rates of mean telomeric loss and accelerated cellular senescence. Senescence has been proposed as a candidate mechanism for the ageing of mitotic tissue. However, some mitotic tissues (such as the immune system) seem...
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