Article
Absence of premature senescence in Werner's syndrome keratinocytes.
Experimental gerontology - 1 Oct 2016
Ibrahim Badr, Sheerin Angela N, Jennert-Burston Katrin, Bird Joe L E, Massala M V, Illsley Matthew, James S Elizabeth, Faragher Richard G A
Abstract excerpt
Werner's syndrome (WS) is an autosomal recessive genetic disorder caused by loss of function mutation in wrn and is a useful model of premature in vivo ageing. Cellular senescence is a plausible causal mechanism of mammalian ageing and, at the cellular level, WS fibroblasts show premature senescence resulting from a combination of telomeric attrition and replication fork stalling. Over 90% of WS fibroblast...
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