Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Rad51C Deficiency Destabilizes XRCC3, Impairs Recombination, and Radiosensitizes S/G2-phase Cells

30 Jul 2004

Abstract excerpt

The highly conserved Rad51 protein plays an essential role in repairing DNA damage through homologous recombination. In vertebrates, five Rad51 paralogs (Rad51B, Rad51C, Rad51D, XRCC2, and XRCC3) are expressed in mitotically growing cells and are thought to play mediating roles in homologous recombination, although their precise functions remain unclear. Among the five paralogs, Rad51C was found to be a central...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15292210
DOI: 10.1074/jbc.m405212200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Rad51C Deficiency Destabilizes XRCC3, Impairs Recombination, and Radiosensitizes S/G2-phase CellsPMID 15292210Read ↗

Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.Semantic proximity Read ↗

Complex Formation by the Human Rad51B and Rad51C DNA Repair Proteins and Their Activities in VitroSemantic proximity Read ↗

Regulation and pharmacological targeting of RAD51 in cancerSemantic proximity Read ↗

XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.Semantic proximity Read ↗

Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genesSemantic proximity Read ↗

Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.Semantic proximity Read ↗

Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cellsSemantic proximity Read ↗

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions.Semantic proximity Read ↗

Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.Semantic proximity Read ↗

RAD51 Gene Family Structure and FunctionSemantic proximity Read ↗

RAD51C Interacts with RAD51B and Is Central to a Larger Protein Complex in Vivo Exclusive of RAD51Semantic proximity Read ↗

RAD-ical New Insights into RAD51 RegulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.