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Article

Targeting XRCC1 Deficiency in Breast Cancer for Personalized Therapy

20 Dec 2012

Abstract excerpt

XRCC1 is a key component of DNA base excision repair, single strand break repair, and backup nonhomologous end-joining pathway. XRCC1 (X-ray repair cross-complementing gene 1) deficiency promotes genomic instability, increases cancer risk, and may have clinical application in breast cancer. We investigated XRCC1 expression in early breast cancers (n = 1,297) and validated in an independent cohort of estrogen...

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PMID: 23253910
DOI: 10.1158/0008-5472.can-12-2929

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