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Article

Deficiency in BRCA2 leads to increase in non-conservative homologous recombination.

Oncogene - 1 Aug 2002

Larminat Florence, Germanier Maryse, Papouli Efterpi, Defais Martine

Abstract excerpt

The BRCA2 tumor suppressor has been implicated in the maintenance of genomic integrity through a function in cellular responses to DNA damage. The BRCA2 protein directly associates with Rad51, that is essential for repair of double-strand breaks (DSBs) by homologous recombination (HR). In this report, we study the BRCA2-defective Chinese hamster cell mutant V-C8 for its ability to perform homology-directed repair...

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Source

Identifiers

PMID: 12140769
DOI: 10.1038/sj.onc.1205659

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deficiency in BRCA2 leads to increase in non-conservative homologous recombination.PMID 12140769Read ↗

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