Article
Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma.
Carcinogenesis - 1 Jan 2002
Kamiya Yuji, Puzianowska-Kuznicka Monika, McPhie Peter, Nauman Janusz, Cheng Sheue-yann, Nauman Alicja
Abstract excerpt
Thyroid hormone (T(3)) regulates proliferation and differentiation of cells, via its nuclear receptors (TRs). These processes have been shown to be abnormally regulated during carcinogenesis. We have previously found aberrant expression of TRalpha and TRbeta mRNAs in renal clear cell carcinoma (RCCC), suggesting possible involvement of TRs in the carcinogenesis of RCCC. To understand the molecular actions of TRs...
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