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Article

Functionally impaired TR mutants are present in thyroid papillary cancer.

The Journal of clinical endocrinology and metabolism - 1 Mar 2002

Puzianowska-Kuznicka Monika, Krystyniak Agnieszka, Madej Agnieszka, Cheng Sheue-Yann, Nauman Janusz

Abstract excerpt

TRs are transcription factors that regulate cell proliferation, differentiation, and apoptosis. They are cellular homologs of the transcriptionally inactive viral oncogene v-erbA. We tested the hypothesis that the functions of TRs could be impaired in cancer tissues as a result of aberrant expression and/or somatic mutations. As a model system, we selected human thyroid papillary cancer, in which the most common...

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Share to Carcinoma, Papillary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Thyroid Hormone

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Share to Thyroid Hormone Receptors alpha

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Source

Identifiers

PMID: 11889175
DOI: 10.1210/jcem.87.3.8296

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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