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Article

Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire.

Oncogene - 26 Nov 2009

Chan I H, Privalsky M L

Abstract excerpt

Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of normal physiology and development. Mutations in TRs have been identified at high frequency in certain cancers, including human hepatocellular carcinomas (HCCs). The majority of HCC-TR mutants bear lesions within their DNA recognition domains, and we have hypothesized that these lesions change the mutant...

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Share to Carcinoma, Hepatocellular
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

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Share to Protein Structure, Tertiary

Share to Receptors, Thyroid Hormone

Source

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Identifiers

PMID: 19749797
DOI: 10.1038/onc.2009.265
PMCID: PMC2787677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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