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Article

Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire.

Oncogene - 26 Nov 2009

Chan I H, Privalsky M L

Abstract excerpt

Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of normal physiology and development. Mutations in TRs have been identified at high frequency in certain cancers, including human hepatocellular carcinomas (HCCs). The majority of HCC-TR muta...

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Share to Mutation
Share to Carcinoma, Hepatocellular
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Neoplasm Proteins

Share to Protein Structure, Tertiary

Share to Receptors, Thyroid Hormone

Source

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Identifiers

PMID: 19749797
DOI: 10.1038/onc.2009.265
PMCID: PMC2787677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19749797-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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