Article
A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter.
The Journal of biological chemistry - 15 Apr 2005
Kim Sung-Woo, Ho Sung-Chul, Hong Seong-June, Kim Kyung Min, So Edward C, Christoffolete Marcelo, Harney John W
Abstract excerpt
CD44 is an adhesion molecule in the extracellular matrix that shows various functions, including tumor genesis and metastasis. A recent study showed that CD44 expression level was strongly correlated with the generation of papillary thyroid carcinomas, the most prevalent malignancy of the thyroid gland. We report here that CD44 is negatively regulated by thyroid hormone (T(3)) through a novel mechanism. We...
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