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Article

Phenotypic and functional changes in glial cells as a function of age.

Neurobiology of aging - 1 Jan 2000

Yu Wai H, Go Lynle, Guinn Barbara A, Fraser Paul E, Westaway David, McLaurin JoAnne

Abstract excerpt

Both in vivo and in vitro investigations point to an important role for the immune system in the development of age-related neurodegeneration. Microglia isolated from aged female F344 rats, 18-20 months, show a higher percentage of cells with an ameboid morphology indicative of activation, whereas, astrocytes had a quiescent morphology. The ability of astrocytes and microglia to attenuate toxin-induced neuronal...

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PMID: 11755025
DOI: 10.1016/s0197-4580(01)00258-5

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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