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Article

Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice.

Brain, behavior, and immunity - 1 Jul 2012

Kohman Rachel A, DeYoung Erin K, Bhattacharya Tushar K, Peterson Lindsey N, Rhodes Justin S

Abstract excerpt

Aging is associated with low-grade neuroinflammation including primed microglia that may contribute to deficits in neural plasticity and cognitive function. The current study evaluated whether exercise modulates division and/or activation state of microglia in the dentate gyrus of the hippocampus, as activated microglia can express a classic inflammatory or an alternative neuroprotective phenotype. We also...

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Identifiers

PMID: 22056294
DOI: 10.1016/j.bbi.2011.10.006
PMCID: PMC3275652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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