Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A defective NF-kappa B/RelB pathway in autoimmune-prone New Zealand black mice is associated with inefficient expansion of thymocyte and dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2002

Valéro René, Baron Marie-Laurence, Guérin Sandrine, Béliard Sophie, Lelouard Hugues, Kahn-Perles Brigitte, Vialettes Bernard, Nguyen Cathy, Imbert Jean, Naquet Philippe

Abstract excerpt

New Zeland Black (NZB) mice develop an autoimmune disease involving an abnormal B cell response to peripheral self Ags. This disease is associated with defects in other cell types and thymic stromal organization. We present evidence that NZB cells of various lineages, including thymocytes, fibroblasts, and dendritic precursor cells, show impaired proliferation and enhanced cell death in culture upon stimulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to CD3 Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Interleukin-1

Share to Mice, Inbred NOD

Share to Mice, Inbred NZB

Share to T-Lymphocyte Subsets

Share to Thymus Gland

Source

Identifiers

PMID: 12077244
DOI: 10.4049/jimmunol.169.1.185

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A defective NF-kappa B/RelB pathway in autoimmune-prone New Zealand black mice is associated with inefficient expansion of thymocyte and dendritic cells.PMID 12077244Read ↗

Lupus resistance is associated with marginal zone abnormalities in an NZM murine model.Semantic proximity Read ↗

NF-κB: At the Borders of Autoimmunity and Inflammation.Semantic proximity Read ↗

Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunitySemantic proximity Read ↗

Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice.Semantic proximity Read ↗

The Transcription Factor NF-κB in Stem Cells and DevelopmentSemantic proximity Read ↗

Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains: possible involvement in systemic lupus erythematosus pathogenesis.Semantic proximity Read ↗

Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease.Semantic proximity Read ↗

NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci.Semantic proximity Read ↗

Separation of the New Zealand Black Genetic Contribution to Lupus from New Zealand Black Determined Expansions of Marginal Zone B and B1a CellsSemantic proximity Read ↗

NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunitySemantic proximity Read ↗

Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.Semantic proximity Read ↗

A Key Role for NF-<i>κ</i>B Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector FunctionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.