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Article

B-cell development and maturation.

Seminars in oncology - 1 Aug 1998

Rudin C M, Thompson C B

Abstract excerpt

Approximately 85% of all non-Hodgkin's lymphomas arise from cells of the B lineage. Sequential stages of B-cell development have been defined by molecular markers, and these markers can be used to reclassify lymphoid malignancies as representing maturational arrest and immortalization at specific points in B-cell ontogeny. Several of the factors controlling the ordered rearrangement and expression of the...

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PMID: 9728594

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