Article
B-cell development and maturation.
Seminars in oncology - 1 Aug 1998
Rudin C M, Thompson C B
Abstract excerpt
Approximately 85% of all non-Hodgkin's lymphomas arise from cells of the B lineage. Sequential stages of B-cell development have been defined by molecular markers, and these markers can be used to reclassify lymphoid malignancies as representing maturational arrest and immortalization at specific...
Topics
- Animals
- Antibody Formation
- Apoptosis
- B-Lymphocytes
- Cell Cycle
- Cell Differentiation
- Cell Survival
- Gene Expression
- Gene Rearrangement
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Class Switching
- Lymphoma, B-Cell
- Mutation
- Receptors, Fc
- Signal Transduction