Article
Accumulation of somatic mutations in proliferating T cell clones from children treated for leukemia.
Leukemia - 1 Dec 2001
Finette B A, Homans A C, Rivers J, Messier T, Albertini R J
Abstract excerpt
There is continued controversy as to the sequential steps and mechanism(s) responsible for the in vivo acquisition of multiple mutations during neoplastic transformation. We investigated the in vivo clonality and mutational spectra of hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutations in T cells from children with acute lymphocytic leukemia (ALL) to gain insight into the mutagenic mechanisms...
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