Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a small molecule inhibitor of Sir2p.

Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2001

Bedalov A, Gatbonton T, Irvine W P, Gottschling D E, Simon J A

Abstract excerpt

Sir2p is an NAD(+)-dependent histone deacetylase required for chromatin-dependent silencing in yeast. In a cell-based screen for inhibitors of Sir2p, we identified a compound, splitomicin, that creates a conditional phenocopy of a sir2 deletion mutant in Saccharomyces cerevisiae. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci, and the ribosomal DNA. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors
Share to Histone Deacetylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Naphthalenes

Share to Pyrones

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Share to Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 11752457
DOI: 10.1073/pnas.261574398
PMCID: PMC64992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a small molecule inhibitor of Sir2p.PMID 11752457Read ↗

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.Semantic proximity Read ↗

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.Semantic proximity Read ↗

Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.Semantic proximity Read ↗

A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Sir2 Family of Protein DeacetylasesSemantic proximity Read ↗

Sirtuins in yeast: phenotypes and tools.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.Semantic proximity Read ↗

Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases.Semantic proximity Read ↗

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.Semantic proximity Read ↗

Isolation and characterization of conditional alleles of the yeast SIR2 gene.Semantic proximity Read ↗

Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.