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Article

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.

The Journal of biological chemistry - 26 Dec 2003

Hirao Maki, Posakony Jeffrey, Nelson Melisa, Hruby Henning, Jung Manfred, Simon Julian A, Bedalov Antonio

Abstract excerpt

Sir2 and Hst1 are NAD+-dependent deacetylases involved in transcriptional repression in yeast. The two enzymes are highly homologous yet have different sensitivity to the small-molecule inhibitor splitomicin (compound 1) (Bedalov, A., Gatbonton, T., Irvine, W. P., Gottschling, D. E., and Simon, J. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 15113-15118). We have now defined a critical amino acid residue within...

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PMID: 14534292
DOI: 10.1074/jbc.M308966200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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