Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Newcomb Benjamin, Bedalov Antonio

Abstract excerpt

A multitude of enzymes that modify histones and remodel nucleosomes are required for the formation, maintenance, and propagation of the transcriptionally repressed chromatin state in eukaryotes. Robust phenotypic screens in yeast S. cerevisiae have proved instrumental in identifying these activities and for providing mechanistic insights into epigenetic regulation. These phenotypic assays, amenable for high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Chromatin Assembly and Disassembly
Share to Culture Media

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Ribosomal

Share to Drug Evaluation, Preclinical

Share to Gene Silencing

Share to Genes, Mating Type, Fungal

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 19521823
DOI: 10.1007/978-1-59745-540-4_8
PMCID: PMC2925398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.PMID 19521823Read ↗

Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.Semantic proximity Read ↗

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.Semantic proximity Read ↗

Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants.Semantic proximity Read ↗

Combining functional genomics and chemical biology to identify targets of bioactive compounds.Semantic proximity Read ↗

Genetic dissection of histone function.Semantic proximity Read ↗

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.Semantic proximity Read ↗

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.Semantic proximity Read ↗

HistoneHits: a database for histone mutations and their phenotypes.Semantic proximity Read ↗

A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of a small molecule inhibitor of Sir2p.Semantic proximity Read ↗

Revealing complex traits with small molecules and naturally recombinant yeast strains.Semantic proximity Read ↗

Screen time: an unbiased search for histone mutations that affect quiescence and chronological aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.