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Article

Isolation and characterization of conditional alleles of the yeast SIR2 gene.

Journal of molecular biology - 13 Apr 2007

Hickman Merrit, McCullough Kalyani, Woike Adrienne, Raducha-Grace Laura, Rozario Tania, Dula Mary Lou, Anderson Erica, Margalit Danielle, Holmes Scott G

Abstract excerpt

Sir2 is a protein deacetylase that mediates transcriptional silencing at the HM loci, telomeres, and rDNA repeats in yeast. To identify functionally significant regions of the Sir2 protein, we have characterized two types of mutations. First, we used random mutagenesis to create temperature-sensi...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 17316680
DOI: 10.1016/j.jmb.2007.01.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17316680-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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