Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.

Combinatorial chemistry & high throughput screening - 1 Nov 2004

Posakony Jeff, Hirao Maki, Bedalov Antonio

Abstract excerpt

Yeast Sir2 is a defining member of a large family of protein deacetylases found in organisms ranging from bacteria to humans. SIR2 was discovered as a gene required for mating in S. cerevisiae 25 years ago, but it was only recently that Sir2's activity as an NAD-dependent protein deacetylase was established. However, years of extensive research did generate a large body of knowledge about the cellular roles of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors
Share to Histone Deacetylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Naphthalenes

Share to Pyrones

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Share to Sirtuins

Share to Yeasts

Source

Identifiers

PMID: 15578928
DOI: 10.2174/1386207043328346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.PMID 15578928Read ↗

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.Semantic proximity Read ↗

The Sir2 Family of Protein DeacetylasesSemantic proximity Read ↗

Identification of a small molecule inhibitor of Sir2p.Semantic proximity Read ↗

A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sirtuins in yeast: phenotypes and tools.Semantic proximity Read ↗

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.Semantic proximity Read ↗

Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.Semantic proximity Read ↗

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.Semantic proximity Read ↗

Diversity in the Sir2 family of protein deacetylasesSemantic proximity Read ↗

Bypassing the catalytic activity of SIR2 for SIR protein spreading in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity.Semantic proximity Read ↗

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.