Article
Chronic soluble antigen sensitization primes a unique memory/effector T cell repertoire associated with th2 phenotype acquisition in vivo.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2002
Foucras Gilles, Gallard Alexandra, Coureau Christiane, Kanellopoulos Jean-M, Guéry Jean-Charles
Abstract excerpt
Although much progress has been made in characterization of the signaling pathways that control Th cell commitment, little is known about the early events that govern differentiation of IL-4-producing T lymphocytes in vivo. We have previously shown that chronic administration of low dose, soluble hen egg white lysozyme (HEL) induced the selective development of Ag-specific Th2 in genetically predisposed BALB/c...
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