Article
Antigen experience shapes phenotype and function of memory Th1 cells.
PloS one - 1 Jan 2013
Khanolkar Aaruni, Williams Matthew A, Harty John T
Abstract excerpt
Primary and secondary (boosted) memory CD8 T cells exhibit differences in gene expression, phenotype and function. The impact of repeated antigen stimulations on memory CD4 T cells is largely unknown. To address this issue, we utilized LCMV and Listeria monocytogenes infection of mice to characterize primary and secondary antigen (Ag)-specific Th1 CD4 T cell responses. Ag-specific primary memory CD4 T cells...
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