Article
T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice.
Clinical immunology and immunopathology - 1 Apr 1995
Garlisi C G, Falcone A, Kung T T, Stelts D, Pennline K J, Beavis A J, Smith S R, Egan R W, Umland S P
Abstract excerpt
In a murine model of pulmonary inflammation, aerosolized antigen challenge of sensitized B6D2F1 mice leads to eosinophil accumulation within the lungs. Little is known of the role of T cells and their cytokine products in these allergic animals. In this study, we show that T cells migrate into the lungs in response to antigen challenge and are necessary for local production of cytokines (IL-4 and IL-5) important...
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