Article
T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice.
Clinical immunology and immunopathology - 1 Apr 1995
Garlisi C G, Falcone A, Kung T T, Stelts D, Pennline K J, Beavis A J, Smith S R, Egan R W, Umland S P
Abstract excerpt
In a murine model of pulmonary inflammation, aerosolized antigen challenge of sensitized B6D2F1 mice leads to eosinophil accumulation within the lungs. Little is known of the role of T cells and their cytokine products in these allergic animals. In this study, we show that T cells migrate into th...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens
- Bronchoalveolar Lavage Fluid
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Carrier Proteins
- Cytokines
- Eosinophils
- Hyaluronan Receptors
- Immunologic Memory
- Interleukin-4
- Interleukin-5
- Isoantibodies
- Lung
- Lymphocyte Activation
- Male
- Mice