Article
Detection of protein on BTLAlow cells and in vivo antibody-mediated down-modulation of BTLA on lymphoid and myeloid cells of C57BL/6 and BALB/c BTLA allelic variants.
Immunobiology - 1 Jul 2010
del Rio Maria-Luisa, Kaye Jonathan, Rodriguez-Barbosa Jose-Ignacio
Abstract excerpt
B- and T-lymphocyte attenuator (BTLA, CD272) is a polymorphic molecule belonging to the Ig superfamily (SF) that attenuates BCR and TCR-mediated signaling, and thereby functions as a negative regulator of lymphocyte activation. Herein, we report an anti-murine BTLA mAb (clone 4G12b) that remarkably detects protein expression on BTLA(low) cells such as naïve CD4(+) cells, CD8(+) T cells, dendritic cells (DC), as...
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