Article
Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR.
International immunology - 1 Aug 1999
Saparov A, Kraus L A, Cong Y, Marwill J, Xu X Y, Elson C O, Weaver C T
Abstract excerpt
The majority of clonotypic CD4(+) T cells in the intestinal lamina propria of DO11.10 TCR transgenic mice have an activated/memory phenotype and produce effector cytokines despite the absence of prior exposure to ovalbumin (OVA), the transgene-specific antigen. A small number of splenic T cells have a similar phenotype. Clonotypic T cells from Peyer's patch are intermediate in both phenotype and effector cytokine...
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