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Article

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.

Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2004

Eyquem Stéphanie, Chemin Karine, Fasseu Magali, Bories Jean-Christophe

Abstract excerpt

The pre-T cell receptor (TCR) functions as a critical checkpoint during alphabeta T cell development. Signaling through the pre-TCR controls the differentiation of immature CD4(-)CD8(-)CD25(+)CD44(-) [double-negative (DN)3] thymocytes into CD4(+)CD8(+) double-positive (DP) cells through the CD4(-)CD8(-)CD25(-)CD44(-)(DN4) stage. In addition, pre-TCR activity triggers expansion and survival of thymocytes and...

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Identifiers

PMID: 15496469
DOI: 10.1073/pnas.0405546101
PMCID: PMC524847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.PMID 15496469Read ↗

TCRbeta transmembrane tyrosines are required for pre-TCR function.Semantic proximity Read ↗

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.Semantic proximity Read ↗

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Semantic proximity Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Pleiotropic changes controlled by the pre-T-cell receptor.Semantic proximity Read ↗

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.Semantic proximity Read ↗

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.Semantic proximity Read ↗

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.Semantic proximity Read ↗

Receptor-specific allelic exclusion of TCRV alpha-chains during development.Semantic proximity Read ↗

Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.Semantic proximity Read ↗

E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.Semantic proximity Read ↗

The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action.Semantic proximity Read ↗

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