Article
The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.
Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2004
Eyquem Stéphanie, Chemin Karine, Fasseu Magali, Bories Jean-Christophe
Abstract excerpt
The pre-T cell receptor (TCR) functions as a critical checkpoint during alphabeta T cell development. Signaling through the pre-TCR controls the differentiation of immature CD4(-)CD8(-)CD25(+)CD44(-) [double-negative (DN)3] thymocytes into CD4(+)CD8(+) double-positive (DP) cells through the CD4(-)CD8(-)CD25(-)CD44(-)(DN4) stage. In addition, pre-TCR activity triggers expansion and survival of thymocytes and...
Topics
- Alleles
- Animals
- Apoptosis
- Cell Cycle
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Proto-Oncogene Protein c-ets-1
- Proto-Oncogene Proteins