Article
Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 2001
Deinum J, van Gool J M, Kofflard M J, ten Cate F J, Danser A H
Abstract excerpt
The development of left ventricular hypertrophy in subjects with hypertrophic cardiomyopathy (HCM) is variable, suggesting a role for modifying factors such as angiotensin II. Angiotensin II mediates both trophic and antitrophic effects, via angiotensin II type 1 (AT(1)-R) and angiotensin II type 2 (AT(2)-R) receptors, respectively. Here we investigated the effect of the AT(2)-R gene A/C(3123) polymorphism,...
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