Article
Role of candidate modifier genes on the phenotypic expression of hypertrophy in patients with hypertrophic cardiomyopathy.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Dec 1997
Brugada R, Kelsey W, Lechin M, Zhao G, Yu Q T, Zoghbi W, Quinones M, Elstein E, Omran A, Rakowski H, Wigle D, Liew C C, Sole M, Roberts R, Marian A J
Abstract excerpt
BACKGROUND: The phenotypic expression of left ventricular hypertrophy (LVH) in patients with hypertrophic cardiomyopathy (HCM) is variable. This phenotypic variability is not completely explained by the responsible mutations or other known factors. Recent data denote a role for the modifier genes...
Topics
- Adult
- Angiotensinogen
- Cardiomyopathy, Hypertrophic
- DNA Primers
- Endothelin-1
- Female
- Gene Expression
- Genotype
- Humans
- Hypertrophy, Left Ventricular
- Male
- Middle Aged
- Phenotype
- Polymerase Chain Reaction