Article
Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy.
Human genetics - 1 Aug 2008
van der Merwe Lize, Cloete Ruben, Revera Miriam, Heradien Marshall, Goosen Althea, Corfield Valerie A, Brink Paul A, Moolman-Smook Johanna C
Abstract excerpt
Hypertrophic cardiomyopathy, a common, inherited cardiac muscle disease, is primarily caused by mutations in sarcomeric protein-encoding genes and is characterized by overgrowth of ventricular muscle that is highly variable in extent and location. This variability has been partially attributed to locus and allelic heterogeneity of the disease-causing gene, but other factors, including unknown genetic factors,...
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