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Article

Cardiac aldosterone in subjects with hypertrophic cardiomyopathy.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Dec 2006

Chai Wenxia, Hoedemaekers Yvonne, van Schaik Ron H N, van Fessem Marianne, Garrelds Ingrid M, Saris Jasper J, Dooijes Dennis, ten Cate Folkert J, Kofflard Marcel M J, Danser A H Jan

Abstract excerpt

Left ventricular (LV) hypertrophy in subjects with hypertrophic cardiomyopathy (HCM) is variable, suggesting a role for modifying factors. Here, we determined whether aldosterone modulates hypertrophy in HCM. Cardiac and/or plasma aldosterone were measured in organ donors and HCM patients. The effect of the aldosterone synthase ( CYP11B2 ) C-344T polymorphism on LV mass index (LVMI) and interventricular septum...

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Identifiers

PMID: 17318792
DOI: 10.3317/jraas.2006.042

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ACE

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