Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.

doi:10.1002/gcc.1207

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Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.

Genes, chromosomes & cancer - 1 Jan 2002

Miller Carl W, Ikezoe Takayuki, Krug Utz, Hofmann Wolf-K, Tavor Sigal, Vegesna Vijaya, Tsukasaki Kunihiro, Takeuchi Seisho, Koeffler H Phillip

Abstract excerpt

Checkpoint genes, activated in response to DNA damage and other stresses, are frequently targeted for alteration in cancer. Checkpoint kinase 2 (CHK2, CDS1, RAD53) is activated by ataxia telangiectasia mutated (ATM) in response to gamma irradiation. Activated CHK2 stabilizes TP53, and acts on other cell cycle and stress regulators. These findings place CHK2 in the middle of a pathway frequently targeted in...

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Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.

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