Article
Mutation analysis of the CHK2 gene in breast carcinoma and other cancers.
Breast cancer research : BCR - 1 Jan 2002
Ingvarsson Sigurdur, Sigbjornsdottir Bjarnveig I, Huiping Chen, Hafsteinsdottir Sigridur H, Ragnarsson Gisli, Barkardottir Rosa B, Arason Adalgeir, Egilsson Valgardur, Bergthorsson Jon T H
Abstract excerpt
BACKGROUND: Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in response to DNA damage and is involved in cell-cycle pathways and p53 pathways. METHODS: We screened 139 breast tumors for loss of heterozygosity at chromosome 22q, using seven microsatellite markers, and screened 119 breast tumors with...
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