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Article

Mutation analysis of the CHK2 gene in breast carcinoma and other cancers.

Breast cancer research : BCR - 1 Jan 2002

Ingvarsson Sigurdur, Sigbjornsdottir Bjarnveig I, Huiping Chen, Hafsteinsdottir Sigridur H, Ragnarsson Gisli, Barkardottir Rosa B, Arason Adalgeir, Egilsson Valgardur, Bergthorsson Jon T H

Abstract excerpt

BACKGROUND: Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in response to DNA damage and is involved in cell-cycle pathways and p53 pathways. METHODS: We screened 139 breast tumors for loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 12052256
DOI: 10.1186/bcr435
PMCID: PMC111029

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12052256-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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