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Article

Characterization of tumor-associated Chk2 mutations.

The Journal of biological chemistry - 26 Jan 2001

Wu X, Webster S R, Chen J

Abstract excerpt

The integrity of the DNA damage response pathway is essential for prevention of neoplastic transformation. Several proteins involved in this pathway including p53, BRCA1, and ATM are frequently mutated in human cancer. Checkpoint kinase 2 (Chk2) is a DNA damage-activated protein kinase that lies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11053450
DOI: 10.1074/jbc.M009727200

Genes

ATM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11053450-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Characterization of tumor-associated Chk2 mutations.PMID 11053450Read ↗

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