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Article

Alternative splicing and mutation status of CHEK2 in stage III breast cancer.

Oncogene - 4 Nov 2004

Staalesen Vidar, Falck Jacob, Geisler Stephanie, Bartkova Jirina, Børresen-Dale Anne-Lise, Lukas Jiri, Lillehaug Johan Richard, Bartek Jiri, Lønning Per Eystein

Abstract excerpt

The DNA damage checkpoint kinase, CHK2, promotes growth arrest or apoptosis through phosphorylating targets such as Cdc25A, Cdc25C, BRCA1, and p53. Both germline and somatic loss-of-function CHEK2 mutations occur in human tumours, the former linked to the Li-Fraumeni syndrome, and the latter found in diverse types of sporadic malignancies. Here we examined the status of CHK2 by genetic and immunohistochemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15361853
DOI: 10.1038/sj.onc.1207928

Genes

CHEK2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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