Article
Caffeine and the G2/M block override: a concept resulting from a misleading cell kinetic delay, independent of functional p53.
International journal of cancer - 1 Nov 2001
Deplanque G, Céraline J, Mah-Becherel M C, Cazenave J P, Bergerat J P, Klein-Soyer C
Abstract excerpt
In the literature the sensitization of DNA to radiation-induced damage by caffeine has been attributed to an override of the G2/M block. This process was supposed to involve the tumor suppressor gene p53 as it was described that p53 negative cells were more sensitive to checkpoint inhibition by caffeine than the wildtype phenotype. We have recently shown that caffeine does not cause an override of the G2/M block...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.