Article
Requirement for p53 and p21 to sustain G2 arrest after DNA damage.
Science (New York, N.Y.) - 20 Nov 1998
Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown J P, Sedivy J M, Kinzler K W, Vogelstein B
Abstract excerpt
After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell cycle. It is shown here that this arrest could be sustained only when p53 was present in the cell and capable of transcriptionally activating the cyclin-dependent kinase inhibitor p21. After disruption of...
Topics
- Apoptosis
- CDC2 Protein Kinase
- Cell Line
- Cyclin B
- Cyclin B1
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA
- DNA Damage
- G2 Phase
- Gamma Rays
- Gene Expression Regulation
- Genes, p53
- Humans
- Mitosis
- Mutation
- Nocodazole
- Tumor Cells, Cultured