Article
Radiation induced G1-block and p53 status in six human cell lines.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 1995
Zölzer F, Hillebrandt S, Streffer C
Abstract excerpt
Considerable attention has recently been focused on the fact that the tumor suppressor protein p53 is involved in the cellular response to radiation. In its wild-type form the protein appears to control a cell cycle checkpoint, preventing entry into S-phase following DNA damage. A number of autho...
Topics
- Antimetabolites
- Bromodeoxyuridine
- Carcinoma, Squamous Cell
- Cell Cycle
- Cell Cycle Proteins
- Cell Division
- Cell Line, Transformed
- Culture Media, Serum-Free
- DNA Damage
- DNA, Neoplasm
- Fibroblasts
- G1 Phase
- Humans
- Male
- Melanoma
- Middle Aged
- Mutation
- Radiotherapy Dosage