Article
Radiation induced G1-block and p53 status in six human cell lines.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 1995
Zölzer F, Hillebrandt S, Streffer C
Abstract excerpt
Considerable attention has recently been focused on the fact that the tumor suppressor protein p53 is involved in the cellular response to radiation. In its wild-type form the protein appears to control a cell cycle checkpoint, preventing entry into S-phase following DNA damage. A number of authors observed a radiation induced G1-block in cells expressing wild-type p53, but not in p53 mutant cells. We obtained...
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