Article
Relaxed cell-cycle arrests and propagation of unrepaired chromosomal damage in cancer cell lines with wild-type p53.
Molecular carcinogenesis - 1 Sept 1998
Olivier M, Bautista S, Vallès H, Theillet C
Abstract excerpt
The role of the p53 protein in mediating G1 and G2 cell-cycle arrests after genotoxic insult has been clearly and reproducibly established in primary diploid fibroblasts, but data obtained from p53 wild-type (wt) cancer cell lines are inconsistent. Furthermore, a large proportion of human tumors...
Topics
- Breast Neoplasms
- Cell Cycle
- Chromosome Aberrations
- DNA Damage
- Gamma Rays
- Genes, p53
- Humans
- Mutagens
- Mutation
- Oncogene Protein p21(ras)
- Oxidative Stress
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53