Article
Relaxed cell-cycle arrests and propagation of unrepaired chromosomal damage in cancer cell lines with wild-type p53.
Molecular carcinogenesis - 1 Sept 1998
Olivier M, Bautista S, Vallès H, Theillet C
Abstract excerpt
The role of the p53 protein in mediating G1 and G2 cell-cycle arrests after genotoxic insult has been clearly and reproducibly established in primary diploid fibroblasts, but data obtained from p53 wild-type (wt) cancer cell lines are inconsistent. Furthermore, a large proportion of human tumors have p53 wt genotypes but present genetic aberrations that may result from defective cell-cycle checkpoints. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.