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DNA damage and p53-mediated cell cycle arrest: A reevaluation

24 Dec 1996

Abstract excerpt

Most mammalian cells exhibit transient delays in the G1 and G2 phases of the cell cycle after treatment with radiation or radiomimetic compounds. p53 is required for the arrest in G1, which provides time for DNA repair. Recently, a role of p53 in the G2/M transition has also been suggested. However, it has been reported that the presence of functional p53 does not always correlate with the induction of these...

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PMID: 8986789
DOI: 10.1073/pnas.93.26.15209

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