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Article

Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation.

Archives of biochemistry and biophysics - 1 Apr 2003

Minemoto Yuzuru, Uchida Sanae, Ohtsubo Motoaki, Shimura Mari, Sasagawa Toshiyuki, Hirata Masato, Nakagama Hitoshi, Ishizaka Yukihito, Yamashita Katsumi

Abstract excerpt

Most cell lines that lack functional p53 protein are arrested in the G2 phase of the cell cycle due to DNA damage. When the G2 checkpoint is abrogated, these cells are forced into mitotic catastrophe. A549 lung adenocarcinoma cells, in which p53 was eliminated with the HPV16 E6 gene, exhibited ef...

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Source

Identifiers

PMID: 12646262
DOI: 10.1016/s0003-9861(03)00010-9

Genes

CDK1
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12646262-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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