Article
Genetic background influences the behavioural and molecular consequences of neurokinin-1 receptor knockout.
The European journal of neuroscience - 1 Feb 2008
McCutcheon J E, Fisher A S, Guzdar E, Wood S A, Lightman S L, Hunt S P
Abstract excerpt
Genetic background affects animal phenotype and therefore is of particular relevance to studies using genetically manipulated mice. Strain differences in hypothalamic-pituitary-adrenocortical (HPA) axis activity may contribute to background-specificity of some mutations. Here, we analysed components of the HPA axis in mice lacking a functional neurokinin-1 receptor (NK1-/-) on two backgrounds: backcrossed C57BL/6...
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