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Article

NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD.

Journal of psychopharmacology (Oxford, England) - 1 Jan 2010

Yan T C, McQuillin A, Thapar A, Asherson P, Hunt S P, Stanford S C, Gurling H

Abstract excerpt

Mice with functional genetic ablation of the Tacr1 (substance P-preferring receptor) gene (NK1R-/-) are hyperactive. Here, we investigated whether this is mimicked by NK1R antagonism and whether dopaminergic transmission is disrupted in brain regions that govern motor performance. The locomotor activity of NK1R-/- and wild-type mice was compared after treatment with an NK1R antagonist and/or psychostimulant...

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Source

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Identifiers

PMID: 19204064
DOI: 10.1177/0269881108100255
PMCID: PMC3943619

Genes

TACR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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