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Article

Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain of CFTR.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2002

Zhang Zhi-Ren, Zeltwanger Shawn, Smith Stephen S, Dawson David C, McCarty Nael A

Abstract excerpt

A mutation in the fifth transmembrane domain of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel (V317E) resulted in whole cell currents that exhibited marked outward rectification on expression in Xenopus oocytes. However, the single-channel unitary current (i)-voltage (V) relationship failed to account for the rectification of whole cell currents. In excised patches containing one to...

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Source

Identifiers

PMID: 11741825
DOI: 10.1152/ajplung.2002.282.1.L135

Genes

CFTR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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